ABSTRACT
Urinary parameters related to acid base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (l8HOB) during 1,3 or 5 days, under basal conditions and after gravage with 200 mM HCI. The results showed: a) a persistent effect of B and l8HOB increasing titratable acidity principally in response to acidosis; b) an increased phosphate elimination in acidotic B treated ADX on the first day, and in 18 HOB treated ADX on days 3 and 5; c) pronounced increases in blood pH and blood bicarbonate levels provoked by the three steroids on day 1; d) increments of ammonium elimination in response to acidosis by aldo treatmets on the first day, while B and l8HOB increase ammonium elimination under almost all conditions during the whole experiment; e) the effects of B and 18 HOB would be independent of an increase in sodium retention as well as glomerular filtration rate.
Subject(s)
Rats , Animals , Male , Aldosterone/pharmacology , Corticosterone/analogs & derivatives , Corticosterone/pharmacology , Homeostasis/drug effects , Kidney/drug effects , Hydrogen-Ion Concentration/drug effects , Rats, Sprague-Dawley , UrinalysisABSTRACT
Estudiamos la unión específica de la 18-hidroxicorticosterona (18-OH-B) a fracciones nucleares y citoplasmáticas de células provenientes de bulbo, protuberancia, amígdala, pituitaria anterior, hipotálamo, hipocampo, área preóptica y pulmón de animales adrenalectomizados, después de incubar los tejidos con el ligando radiactivo. Encontramos que 18-OH-B tiene una mayor unión específica a núcleos obtenidos de bulbo y protuberancia; este perfil difiere de observaciones previas en las que otros corticosteroide íntimamente relacionados, como la corticosterona y la aldosterona, se encuentran principalmente concentrados en el sistema límbico
Subject(s)
Animals , Male , Rats , 18-Hydroxycorticosterone/metabolism , Central Nervous System/metabolism , Subcellular Fractions/metabolism , In Vitro Techniques , Adrenalectomy , Binding Sites , Central Nervous System/cytology , Rats, Inbred StrainsABSTRACT
Se determinaron los niveles plasmáticos de corticosteroma de ratas en diferentes períodos después de la adrenalectomía, utilizando cromatografía líquida de alta presión (HPLC) y/o cromatografía gas-líquido (GLC). Se encontraron niveles mínimos 24 a 48 horas después de la operación